Multi-Fluorescence Imaging of Protein Crystals

April 24, 2017 by Lance Ramsey Leave a Comment
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Posted in: Protein Crystallization, imaging, protein-protein complexes, membrane proteins, protein crystals

Unprecedented Sensitivity for API Crystalline Quantification using SONICC

April 14, 2017 by Lance Ramsey Leave a Comment

SONICC (Second Order Nonlinear Imaging of Chiral Crystals) is a novel imaging technique that offers unprecedented sensitivity in quantifying small molecule crystallinity. SONICC can be used to detect concentrations of crystalline APIs down to...

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Posted in: SONICC, Amorphous solid dispersions, api, crystallinity, chiral crystals, Active Pharmaceutical Ingredients

Active Pharmaceutical Ingredient Characterization using SONICC

April 12, 2017 by Lance Ramsey Leave a Comment

SONICC (Second Order Nonlinear Imaging of Chiral Crystals) uses a femtosecond pulsed laser to exploit the frequency-doubling effect produced by the majority of Active Pharmaceutical Ingredients (APIs) and allows for 2-orders of magnitude...

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Posted in: SONICC, Amorphous solid dispersions, Active Pharmaceutical Ingredients

Cold Spring Harbor Asia - Membrane Proteins: Structure & Function

April 10, 2017 by Lance Ramsey Leave a Comment
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Posted in: Protein Crystallization, Rock Maker, NT8, Rock Imager, SONICC, FRAP, lipidic cubic phase, lcp, mfi, membrane proteins

Detection and Imaging of Protein Microcrystals using SONICC

April 06, 2017 by Lance Ramsey Leave a Comment

Authors: Ellen Gualtieri, Eric Zhou, Lance RamseyAbout SONICCSONICC, Second Order Non-linear Imaging of Chiral Crystals, uses a femtosecond pulsed laser to exploit the frequency-doubling effect found in the majority of protein crystals, and...

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Posted in: Protein Crystallization, SONICC, imaging, lcp, membrane proteins, protein crystals

British Crystallographic Association Spring Meeting 2017

April 04, 2017 by Lance Ramsey Leave a Comment
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Posted in: Protein Crystallization, Rock Maker, NT8, Rock Imager, SONICC, mfi

Join us at the 14th Annual SER-CAT Symposium

March 28, 2017 by Lance Ramsey Leave a Comment
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Posted in: Protein Crystallization, Rock Imager, SONICC, mfi

Prescreening Membrane Protein Crystallization Conditions with FRAP

March 24, 2017 by Lance Ramsey Leave a Comment

Authors: Ellen Gualtieri1, Eugene Chun2, Wei Liu2, Lance Ramsey11Formulatrix, Inc. 2Arizona State University

Problem:Finding the optimal conditions to crystallize integral membrane proteins is time consuming. Crystals can take two weeks or more...

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Posted in: Protein Crystallization, FRAP, imaging, lcp, prescreening conditions

Multi-Fluorescent Imaging for Sensitive Protein Crystallization Detection

February 21, 2017 by Lance Ramsey Leave a Comment

Problem:The unambiguous and reliable identification of biological crystals remains a major obstacle in crystallography, particularly in the critical stage of initial screening experiments. Automated imaging at high-resolution in the visible range...

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Posted in: Protein Crystallization, UV, imaging, protein-protein complexes

Join us at the 2017 West Coast Protein Crystallography Workshop

February 21, 2017 by Lance Ramsey Leave a Comment
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Posted in: Protein Crystallization, NT8