SHG overhauls XPRD: 10-fold Improved Sensitivity in Crystallinity Detection within Amorphous Solid Dispersions

September 28, 2017 by Lance Ramsey Leave a Comment

Amorphous solid dispersion formulations are utilized for poorly water soluble active pharmaceutical ingredients (APIs) in an attempt to increase bioavailability and dissolution kinetics. Spray dry methods are used to generate amorphous dispersions...

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Posted in: SONICC, Amorphous solid dispersions, Active Pharmaceutical Ingredients, XPRD

Rapid, Sensitive Detection of Polymorph Transitions in Drug Formulations Utilizing SHG guided Raman Spectroscopy

September 28, 2017 by Lance Ramsey Leave a Comment

Enantiomerically pure active pharmaceutical ingredient (API) formulations are often essential in delivering an effective and bioavailable drug. APIs can exhibit polymorphism, meaning that the small molecule can crystallize into multiple forms. Both,...

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Posted in: SONICC, Amorphous solid dispersions, Active Pharmaceutical Ingredients, Raman

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