SHG overhauls XPRD: 10-fold Improved Sensitivity in Crystallinity Detection within Amorphous Solid Dispersions

September 28, 2017 by Lance Ramsey Leave a Comment

Enantiomerically pure active pharmaceutical ingredient (API) formulations are often essential in delivering an effective and bioavailable drug. APIs can exhibit polymorphism, meaning that the small molecule can crystallize into multiple forms. Both,...

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Posted in: SONICC, Amorphous solid dispersions, Active Pharmaceutical Ingredients, XPRD

Rapid, Sensitive Detection of Polymorph Transitions in Drug Formulations Utilizing SHG guided Raman Spectroscopy

September 28, 2017 by Lance Ramsey Leave a Comment

Enantiomerically pure active pharmaceutical ingredient (API) formulations are often essential in delivering an effective and bioavailable drug. APIs can exhibit polymorphism, meaning that the small molecule can crystallize into multiple forms. Both,...

[Read more…]

Posted in: SONICC, Amorphous solid dispersions, Active Pharmaceutical Ingredients, Raman

Unprecedented Sensitivity for API Crystalline Quantification using SONICC

April 14, 2017 by Lance Ramsey Leave a Comment

SONICC (Second Order Nonlinear Imaging of Chiral Crystals) is a novel imaging technique that offers unprecedented sensitivity in quantifying small molecule crystallinity. SONICC can be used to detect concentrations of crystalline APIs down to...

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Posted in: SONICC, Amorphous solid dispersions, api, crystallinity, chiral crystals, Active Pharmaceutical Ingredients

Active Pharmaceutical Ingredient Characterization using SONICC

April 12, 2017 by Lance Ramsey Leave a Comment

SONICC (Second Order Nonlinear Imaging of Chiral Crystals) uses a femtosecond pulsed laser to exploit the frequency-doubling effect produced by the majority of Active Pharmaceutical Ingredients (APIs) and allows for 2-orders of magnitude...

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Posted in: SONICC, Amorphous solid dispersions, Active Pharmaceutical Ingredients

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