SHG overhauls XPRD: 10-fold Improved Sensitivity in Crystallinity Detection within Amorphous Solid Dispersions

September 28, 2017 by Lance Ramsey Leave a Comment

Amorphous solid dispersion formulations are utilized for poorly water soluble active pharmaceutical ingredients (APIs) in an attempt to increase bioavailability and dissolution kinetics. Spray dry methods are used to generate amorphous dispersions...

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Posted in: SONICC, Amorphous solid dispersions, Active Pharmaceutical Ingredients, XPRD

Rapid, Sensitive Detection of Polymorph Transitions in Drug Formulations Utilizing SHG guided Raman Spectroscopy

September 28, 2017 by Lance Ramsey Leave a Comment

Enantiomerically pure active pharmaceutical ingredient (API) formulations are often essential in delivering an effective and bioavailable drug. APIs can exhibit polymorphism, meaning that the small molecule can crystallize into multiple forms. Both,...

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Posted in: SONICC, Amorphous solid dispersions, Active Pharmaceutical Ingredients, Raman

20th Heart of Europe Biocrystallography Meeting

August 31, 2017 by Lance Ramsey Leave a Comment

Join us at the upcoming 20th Heart of Europe Biocrystallogarphy Meeting at the Palac Wojanow in Poland.  The meeting is being held September 28-30, 2017. 

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Posted in: Protein Crystallization, SONICC, mfi

Join us at the CCP4 Protein Structure Workshop 2017

July 25, 2017 by Lance Ramsey Leave a Comment
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Posted in: Protein Crystallization, SONICC, xfel

Join us at the 21st Swedish Conference on Macromolecular Structure and Function

June 07, 2017 by Lance Ramsey Leave a Comment
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Posted in: Protein Crystallization, Rock Imager, SONICC, mfi

Join us at the 3rd Instruct Biennial Structural Biology Conference

May 09, 2017 by Lance Ramsey Leave a Comment
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Posted in: Protein Crystallization, Rock Imager, SONICC, mfi, aca

Unprecedented Sensitivity for API Crystalline Quantification using SONICC

April 14, 2017 by Lance Ramsey Leave a Comment

SONICC (Second Order Nonlinear Imaging of Chiral Crystals) is a novel imaging technique that offers unprecedented sensitivity in quantifying small molecule crystallinity. SONICC can be used to detect concentrations of crystalline APIs down to...

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Posted in: SONICC, Amorphous solid dispersions, api, crystallinity, chiral crystals, Active Pharmaceutical Ingredients

Active Pharmaceutical Ingredient Characterization using SONICC

April 12, 2017 by Lance Ramsey Leave a Comment

SONICC (Second Order Nonlinear Imaging of Chiral Crystals) uses a femtosecond pulsed laser to exploit the frequency-doubling effect produced by the majority of Active Pharmaceutical Ingredients (APIs) and allows for 2-orders of magnitude...

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Posted in: SONICC, Amorphous solid dispersions, Active Pharmaceutical Ingredients

Cold Spring Harbor Asia - Membrane Proteins: Structure & Function

April 10, 2017 by Lance Ramsey Leave a Comment
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Posted in: Protein Crystallization, Rock Maker, NT8, Rock Imager, SONICC, FRAP, lipidic cubic phase, lcp, mfi, membrane proteins

Detection and Imaging of Protein Microcrystals using SONICC

April 06, 2017 by Lance Ramsey Leave a Comment

Authors: Ellen Gualtieri, Eric Zhao, Lance RamseyAbout SONICCSONICC, Second Order Non-linear Imaging of Chiral Crystals, uses a femtosecond pulsed laser to exploit the frequency-doubling effect found in the majority of protein crystals, and...

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Posted in: Protein Crystallization, SONICC, imaging, lcp, membrane proteins, protein crystals

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